What is Pomalidomide:
Pomalidomide is a thalidomide analogue and FDA-approved prescription medication. This medication is widely used to treat Multiple Myeloma (cancer that forms in a type of white blood cell called a plasma cell). Sometimes, you may hear your health specialist refer to pomalidomide as an IMiD agent, which is short for immunomodulating.
The medicine Pomalidomide is:
- Proven promising with dexamethasone if cancer (MM) stops responding to lenalidomide and a proteasome inhibitor (PI).
- A pill (capsule) that can be taken wherever is convenient for you. Pomalidomide is taken with dexamethasone.
- Not a traditional chemotherapy, an infusion, or an injection
Why Pomalidomide:
If Multiple Myeloma stops responding to lenalidomide and a proteasome inhibitor (PI), Pomalidomide in combination with dexamethasone may be effective. Over the course of multiple myeloma, your doctor will monitor your disease/MM progression by evaluating the presence of M protein in the blood. A large boost in this protein, or M spike, can represent that your multiple myeloma has relapsed and is no longer responding to the medicines you’re taking. So, a kind of different treatment approach/option will need to be considered. Pomalidomide capsules have been assessed in those with relapsed/refractory multiple myeloma (RRMM) who had taken lenalidomide and a protease inhibitor (PI).
Mechanism of Action:
Multiple myeloma (MM) is a kind of disease that typically affects the body’s immune/defense system. IMiD/immunomodulating agents, like Pomalidomide, work with the immune system to help combat Multiple Myelomas. Pomalidomide, when taken along with dexamethasone, was demonstrated to work in three different ways in animal models and in vitro:
- Stimulates: Helps boost the function of certain cells used by the immune/defense system to fight myeloma.
- Strikes: Targets and demolishes myeloma cells, even those resistant to the medicine lenalidomide.
- Starves: Helps scale down new myeloma cell growth by limiting the supply of blood.
Possible side effects of Pomalidomide:
While on treatment with this medicine, you may experience side effects. Some of these side effects may be common or serious. It’s necessary to talk to your health specialist about the side effects you feel while taking Pomalidomide. By adjusting or delaying the dose, side effects can be managed, so you can stay on your treatment longer.
The most common side effect of Pomalidomide include:
- Fever
- Low platelets
- Shortness of breath
- Diarrhea
- Constipation
- Back pain
- Nausea Low white blood cells
- Low red blood cells
- Tiredness and weakness
- Upper respiratory tract infection
Serious Side Effects of Pomalidomide:
- Nerve damage
- Possible birth defects (deformed babies) or death of an unborn baby
- Blood clots in the veins, arteries, and lungs; stroke; and heart attack
- Low white blood cells, low platelets, and low red blood cells
- Severe liver complications, including liver failure and death
- Severe allergic reactions and severe skin reactions
- Dizziness and confusion
- Tumor Lysis Syndrome (TLS)
- Risk of new cancers (malignancies)
Your health specialist may tell you to stop taking Pomalidomide if you develop certain serious side effects while on treatment.
Dosage & Administration:
Pomalidomide is a once-daily capsule you can take at home or wherever is convenient for you. The proposed or recommended dosage is pomalidomide 4 mg once daily orally with or without food on Days 1-21 of each 28-day cycle. Pomalidomide is given in combination with dexamethasone (dex). Initiate treatment in females of reproductive age/potential only after a negative pregnancy test. Advise of the significance of monthly pregnancy tests and the need to use two different forms of contraception during treatment and for four weeks (28 days) after completion of treatment. Advise men to always use latex or synthetic condom during any sexual activity with females of reproductive age while taking Pomalidomide and for up to four weeks (28 days) after discontinuing treatment. Pomalidomide 3 mg, 2 mg, and 1 mg doses are also available for dose modification. Depending on where you are in your disease journey, your health specialist will prescribe a dose that suits your requirements. There are several factors that affect how you take your Pomalidomide pills. For example, the dose may change, on behalf of your lab results.
Note: Pomalidomide 4 mg price in India is less and sometimes can vary. If you are looking for this IMiD agent at the most reasonable price, then get in touch with us through our TOLL-FREE: 1800-889-1064. We are WHO-GDP and ISO 9001 2015 certified Pharmaceutical Wholesalers/ Suppliers/ Exporters/ Importers from India of Pomalidomide Capsules.
